#Metoprolol succ er professional
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In conclusion, metoprolol and verapamil are two effective drugs for treatment of stable exercise-induced angina pectoris. Adverse effects were only mild to moderate and did not cause the cessation of treatment in any case.
Metoprolol caused a substantial reduction in the rate-pressure product both at rest and during exercise (p less than 0.001) this variable was not influenced by verapamil. The increase with verapamil was significantly higher (p less than 0.05) than with metoprolol. Exercise capacity increased from 103 +/- 7 to 113 +/- 7 watts (p less than 0.01) with metoprolol and to 119 +/- 6 watts (p less than 0.01) with verapamil. The mean daily rate of anginal attacks and nitroglycerin consumption decreased significantly (p less than 0.01) and to a similar extent with both drugs. At the end of each treatment period a symptom-limited maximal exercise test was performed. The number of anginal attacks and the consumption of nitroglycerin tablets were reported. After 2 weeks the patients were transferred to a second 4 week period of treatment with the other drug. In the succeeding 4 weeks, verapamil in a daily dose of 360 mg or metoprolol, 200 mg twice daily, was administered in double-blind fashion. Twenty patients with stable, exercise-induced angina pectoris took part in a 14 week study that began with a 4 week single blind placebo period. The cardioselective beta adrenoceptor blocking agent metoprolol was compared with the calcium antagonist verapamil in relation to effects on angina pectoris.
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